Rejuran Healer is a polynucleotide (PN) injection placed in small, even blebs across the face to support skin quality, texture and hydration. At ENTER Plastic Surgery, Rejuran Healer in Seoul takes 20–30 minutes of injecting after 30 minutes of numbing cream, and the starting course is three sessions four weeks apart.
Is it for you?
Skin concerns Rejuran Healer is used for
Rejuran works on the quality of the skin itself. It adds no volume to a hollow and does not pull sagging tissue upward, so it is used for thin, dry or dull-looking skin, fine crepey lines and uneven texture while the facial contour stays as it is. The change builds gradually across a course and suits people who want the skin to look rested without anyone noticing a single treatment day.
Planning matters more than usual for visitors. The first course is three sessions spaced four weeks apart, which means either a longer stay in Seoul or repeat trips. If you can visit only once, weigh whether one session is worth the trip, because the clinic's course guidance assumes three. If what bothers you is deep folds, lost volume or jowls, a filler or a lifting treatment is the conversation to have instead.
Usually a good fit
- Thin, dry or dull-looking facial skin
- Fine crepey lines and rough texture
- Wanting gradual change with the face shape unchanged
- Able to return for three sessions four weeks apart
- Comfortable with small injection bumps for a few days
We may suggest waiting
- Deep folds or hollows that need volume
- Sagging that needs lifting
- Active infection, acne flare or open wounds at the site
- Pregnancy or breastfeeding
- Known allergy to any product ingredient
How it works
How Rejuran Healer injections work in the skin
Rejuran is made by PharmaResearch, and its active component is polynucleotide, chains of purified DNA fragments. Placed in the dermis, these molecules are thought to act as a scaffold and a signal for repair cells, and laboratory and clinical work on the related compound PDRN describes a wound-healing effect through adenosine A2A receptors (Squadrito, 2017). That background explains the interest; it does not prove a cosmetic result on its own, and the clinical evidence for PN injections in aesthetic use is still limited (Rho, 2026).
The product is placed with a fine needle as a grid of tiny deposits, each raising a small bump that flattens as the fluid is absorbed over one to three days. ENTER Plastic Surgery is a REJURAN OFFICIAL CERTIFIED CLINIC, a recognition from PharmaResearch, and the menu lists three versions: Rejuran Healer for the face, Rejuran HB and Rejuran Eye for the skin around the eyes.
Skin check and plan
At consultationYour skin type, the areas that look thin or rough and your travel dates are reviewed, and Rejuran Healer, HB or Eye is chosen with the volume for the session.
Numbing the skin
About 30 minutesThe face is cleansed and numbing cream is applied. This waiting time is separate from the injection time.
Injecting the product
20–30 minutesRejuran is placed in small, evenly spaced blebs in the dermis across the planned areas. Each point leaves a small raised bump.
First hours after
3–4 hoursAvoid washing your face or applying makeup for three to four hours so the needle points can close. The bumps flatten over one to three days.
Rejuran options on the ENTER Plastic Surgery menu
| Point of comparison | Rejuran Healer | Rejuran HB | Rejuran Eye |
|---|---|---|---|
| Volume per listed price | 2 cc | 1 cc | 1 cc |
| Typical area | Full face | Face | Skin around the eyes |
| Numbing | Numbing cream | Numbing cream | Numbing cream |
| Starting course | 3 sessions, 4 weeks apart | 3 sessions, 4 weeks apart | 3 sessions, 4 weeks apart |
| Price | ₩300,000 + VAT | ₩300,000 + VAT | ₩180,000 + VAT |
Formulation differences between the three versions are set by the manufacturer; the course is the clinic's general guidance for Rejuran.
Session by session
| When | What to expect |
|---|---|
| Session 1 | First treatment of the planned areas. |
| Session 2, about 4 weeks later | Second treatment at the same spacing. |
| Session 3, about 4 weeks after that | Course complete; effect is then expected to last about 6 months to 1 year. |
| Every 3–6 months | Maintenance sessions, if you want to keep the result. |
Your doctor
Chief Director · Korean board-certified plastic surgeon
“Natural, yet clearly visible change.”Eyelid and facelift surgery at ENTER is planned and performed by Dr. Jang himself.
- NowChief Director, ENTER Plastic Surgery
- TrainingPlastic surgery, Kyung Hee University Medical Center
- FormerChief Director, Jang Plastic Surgery
- FormerDirector, Secret Plastic Surgery
- MemberKSPRS · KSAPS · ISAPS · ESOPRS · ASPS
At a glance
Rejuran Healer at a glance
| Procedure time | 20–30 minutes, plus 30 minutes of numbing cream |
|---|---|
| Anesthesia | Numbing cream |
| Downtime | Bumps flatten in 1–3 days; needle marks 3–7 days |
| Recommended sessions | 3 sessions, 4 weeks apart; then every 3–6 months |
| How long results last | 3–6 months; 6 months to 1 year after 3 sessions |
| Return to exercise | Generally, published guidance for polynucleotide (PN) skin boosters is to avoid strenuous exercise, excess heat and firm massage for 24 hours |
| Earliest flight home | Same day or the next day |
Prices
Rejuran Healer price list in Seoul
Each Rejuran line is priced by the volume used in one session: 2 cc for Rejuran Healer and 1 cc for Rejuran HB or Rejuran Eye. A three-session course is three of those session fees, so multiply the line you need by three when you budget the first round. The amounts exclude VAT (10% VAT is added at payment).
Ask for the numbing cream and any extra volume to appear as itemized lines in your quote, so the total for each visit is clear before you book.
Prices exclude VAT (10% VAT is added at payment).
Recovery
Aftercare timeline for Rejuran Healer
Small raised bumps mark each injection point. Skip face washing and makeup for three to four hours so the needle points can close.
Makeup and concealer can be used to cover marks. Leave the bumps alone and do not press or massage them. A flight home that evening or the following day fits the clinic's guidance.
The injected product is absorbed and the bumps flatten within about one to three days.
Needle marks or bruises can last three to seven days, depending on your skin. Redness, heat or pain that keeps growing should be reported to the clinic straight away.
Time for the next session in the starting course of three.
Safety
Risks and limits of Rejuran Healer
Side effects reported for polynucleotide injections are mostly mild and short-lived. A 2024 systematic review of nine studies with 219 participants found improvements in wrinkles, texture and elasticity reported, and adverse events that were generally minor, while noting low to moderate study quality and no agreed protocol (Lampridou, 2024). If anything unusual appears, contact the clinic instead of treating it yourself.
- Raised bumps, redness and swelling at the injection points for one to three days.
- Needle marks or bruising that can last three to seven days.
- Discomfort during injection, reduced but not removed by numbing cream.
- Infection at an injection site, which needs prompt care.
- Allergic or hypersensitivity reaction to the product.
- Small lumps or uneven texture if product collects in one spot.
Evidence
Research behind this page
- Expert Perspectives: Evidence-Based Applications of Polynucleotides (PNs) in Aesthetic Medicine and DermatologyClinical, Cosmetic and Investigational Dermatology · 2026 · Rho N et al. · doi:10.2147/ccid.s557226
Expert perspective: polynucleotides look promising for biocompatibility and tolerability in aesthetic medicine, but the evidence is still limited and randomized and histological studies are needed.
- Pharmacological Activity and Clinical Use of PDRNFrontiers in Pharmacology · 2017 · Squadrito F et al. · doi:10.3389/fphar.2017.00224
Pharmacology review of PDRN, a compound related to polynucleotides, summarizing experimental and clinical evidence for wound healing mediated by adenosine A2A receptors.
- The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic ReviewJournal of Cosmetic Dermatology · 2024 · Lampridou S et al. · doi:10.1111/jocd.16721
Systematic review of nine studies (219 participants, low to moderate quality): improvements in wrinkles, texture and elasticity were reported with mostly mild, temporary side effects, but protocols lack consensus.
FAQ
Rejuran Healer FAQ
Can I wear makeup after Rejuran Healer?
Yes, from the next day. Makeup and concealer can be used the day after treatment to cover the injection marks. On the treatment day itself, avoid washing your face or applying makeup for three to four hours so the needle points can close.
How long should I stay in Seoul for a Rejuran Healer course?
A single session needs only a day, and the clinic's guidance is that you can fly the same day or the next. The starting course is three sessions four weeks apart, so completing it means staying about two months or planning three separate trips.
Who gives the Rejuran injections?
Rejuran Healer is given at ENTER Plastic Surgery as a medical injection. Dr. Choi Yul, a family medicine specialist, focuses on Botox, injections and pigment treatment at the clinic. If you want to know which doctor will treat you, ask when you book.
Does the Rejuran Healer price include VAT?
No. Rejuran Healer is listed at ₩300,000 + VAT for 2 cc per session, and 10% VAT is added at payment. Rejuran HB and Rejuran Eye are priced per 1 cc. Ask for the numbing cream to be shown as a line in your quote.
How can I book Rejuran Healer from overseas?
Use the form on this page or send us a WhatsApp message, and we will reply as soon as possible. English-speaking staff are available at the clinic. Mention whether you plan one session or the full course, because that changes how the visits are scheduled.
Is a deposit needed to hold a Rejuran appointment?
Deposit and cancellation terms are set for each booking, so ask for them in writing before paying. If you are planning a three-session course across several trips, ask how changing one session date affects the others.
How long does Rejuran Healer last?
The clinic's guidance is about three to six months after a session, and about six months to one year once the course of three is complete. It is not permanent; maintenance sessions every three to six months keep the effect, and results vary from person to person.
Is Rejuran Healer the same as the Rejuran skincare sold in Seoul shops?
No. Rejuran Healer is an injectable medical product placed in the skin by a doctor. The creams, serums and patches sold in stores under the Rejuran name are cosmetics applied on the surface, and they are not a substitute for the injection.
What is a polynucleotide?
A polynucleotide (PN) is a chain of purified DNA fragments. In Rejuran, it is injected into the dermis, where it is thought to support the skin's own repair. It is related to, but not the same as, PDRN, which has been studied for wound healing (Squadrito, 2017).
Is Rejuran Healer worth it?
That depends on your goal and your schedule. Published studies report better texture, elasticity and fine lines with mild side effects, but the quality of the evidence is low to moderate (Lampridou, 2024). It suits people after a gradual change in skin quality who can return for the course.
Is Rejuran Eye an injection or an eye cream?
At ENTER Plastic Surgery, Rejuran Eye is an injection for the thin skin around the eyes, listed at ₩180,000 + VAT per 1 cc. The eye creams, gels and patches sold under the same brand are separate cosmetic products.
Will my insurance pay for Rejuran Healer in Korea?
We cannot tell whether your insurer will cover a cosmetic injection abroad, so check with your provider before you travel. If you need documents for a claim, ask the clinic for an itemized receipt that lists the product and volume used.
Google reviews
Reviews on Google Maps
Great experience! Dr. is very sweet and kind. He listened to what I wanted to fix and correct. He explained everything very well. Wasn’t pushy and didn’t try to sell anything extra. This isn’t a clinic that comes out on instagram, which I…
Jennifer LyuA month agoI came to Enter Plastic Surgery on a friend’s recommendation for under-eye fat repositioning. I was pretty nervous going in, but the doctor took the time to explain what would work for my under-eyes, what the procedure involved, and what…
Michael2 months agoThe staff are incredibly friendly, and the consultation was very thorough. I was very worried since it was my first procedure, but the director explained the aftercare in detail, so I felt completely confident trusting them!!
ROOHEUI SHIN (RHS)2 months ago · Translated by Google