Juvgenin Seoul for Fine Lines and Depressed Scars

The clinic prices Juvgen by area and sorts the areas into two tiers. The first covers thin, finely creased skin: the eye area, the frown lines between the brows (the glabella) and depressed scars. The second covers longer folds on the forehead, beside the nose and mouth (nasolabial folds) and running down from the mouth corners (marionette lines). That split is a useful way to think about whether the treatment matches your concern, because Juvgen acts on the quality and creasing of the skin itself.

It does not add much bulk on the day. Where a face has lost fat or bony support, the shadow comes from missing volume, and a volumizing filler or a collagen stimulator such as Sculptra is the more direct conversation. Loose skin along the jaw and cheeks is a lifting question. The change from Juvgen also builds slowly, so the timing has to suit your plans: the clinic describes collagen filling in over four to six weeks after each session.

Juvgen is an injection system from JSDR (J.SELF DERMAL REGENERATION), a company based in Seoul. It sends two materials into the skin in the same pass: medical CO2 gas and hyaluronic acid. The gas half draws on carboxytherapy, an older technique in which carbon dioxide is injected under the skin. A local rise in CO2 widens small blood vessels and makes the surrounding tissue release oxygen more readily, and the gas spreading through the layer creates a mild, controlled disruption. Both are thought to start a repair response that lays down collagen. The hyaluronic acid holds water in the treated layer while that response develops.

The research behind this is on carboxytherapy in general. No published study on the Juvgen device itself was found, so the figures below describe the technique and do not predict a Juvgen result. In a tissue study, the proportion of collagen rose after carboxytherapy compared with untreated control skin, while elastic fibers showed no difference (Oliveira, 2020). A 2022 systematic review found improvement across several skin conditions with mild, short-lived side effects, but the studies were small and measured outcomes in different ways, and the authors called for randomized trials (Ahramiyanpour, 2022).

At the clinic, injectables, Botox and pigment care are the focus of Dr. Choi Yul, a family medicine specialist.

Juvgen is charged by treatment area, not by the syringe or the cc. The lower tier, ₩2,000,000 per area, applies to the eye area, the glabella or a depressed scar. The higher tier, ₩3,000,000 per area, applies to the forehead, the nasolabial folds or the marionette lines. Each figure on this list is shown before tax, and 10% VAT is added at payment.

Two areas in one visit means two area fees. A course runs two to three sessions, so ask for your written quote to state how many areas and how many sessions it covers before you plan the trip.

CO2 injection has a few side effects of its own, separate from those of hyaluronic acid. A 2022 review of carboxytherapy listed unintended loss of fat, gas that lingers under the skin longer than expected and results that fall short of expectations among its drawbacks (Kroumpouzos, 2022).

• Swelling for two to three days, and bruising or needle marks for up to one to two weeks.
• Pressure, aching or a crackling feel under the skin while the gas disperses (subcutaneous emphysema), which can persist.
• Unintended thinning of the fat layer in the treated area.
• Small lumps, uneven texture or a result smaller than hoped for.
• Infection or prolonged redness at needle points.
• With any facial hyaluronic acid injection, a rare blockage of a blood vessel; pain that spreads or a pale or dusky patch of skin needs urgent attention.

The evidence for carboxytherapy is low in quality, and none of it tests the Juvgen device directly, so treat any published improvement as background to the method.